New mitomycin, 10-decarbamoyloxy-9-dehydromitomycin B from Streptomyces caespitosus.
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چکیده
منابع مشابه
Studies in a tumor spectrum. VIII. The effect of mitomycin C on the growth of a variety of mouse, rat, and hamster tumors.
Since the original work of Fleming (1), many antibiotics have been isolated from culture filtrates of soil microorganisms. A few of the antibiotics have demonstrated anti-tumor effects in experimental animals (9, 25). Recently, Hata and his associates (8, 12), Sakai and Teranaka (11), and Teranaka (29) reported that mitomycin C, a new antibiotic isolated from Streptomyces caespitosus (4), has s...
متن کاملThe Off - label Use of Mitomycin C
By Steven D. Vold, MD Isolated from the fungus Streptomyces caespitosus, mitomycin C (MMC) inhibits DNA synthesis, which prevents cells from dividing and growing.1,2 It is this quality that led the FDA to approve MMC for the treatment of advanced stomach and pancreatic cancer in combination with other chemotherapeutic agents. MMC is also currently widely used in ophthalmology, including glaucom...
متن کاملEffects of mitomycin C administered at various stages of pregnancy upon mouse fetuses.
Many cancer therapeutic agents have been used for experimental and clinical purposes. It has been established that generally such agents are toxic to embryos with highly mitotic activities as well as other rapidly growing or proliferating tissues. The teratogenicity of these agents has been shown in rodents (Reviewed by Nishimura, '64; Karnof sky, '65; Dagg, '66). Murphy et at. ('58) found that...
متن کاملThe Effect of Mitomycin-c on the Nucleolar Fine Structure of Kb Cells in Cell Culture.
et al. (7) in 1956 from Streptomyces caespitosus. Its selective effect on deoxyribonucleic acid (DNA), especially in bacterial systems, has been demonstrated (15, 16, 52, 53). This agent also proved to be toxic for proliferating tissues in animals. Hypoplasia of bone marrow, lymphoid tissue damage, and lesions in intestinal epithelium have been reported as common pathologic effects of MC treat ...
متن کاملA new site-specific endonuclease, ScaI, from Streptomyces caespitosus.
A new site-specific endonuclease has been isolated from Streptomyces caespitosus and named ScaI. Based on analysis of sequences around the restriction sites in pBR322 and pBR325, the recognition sequence of ScaI endonuclease was deduced to be a new hexanucleotide 5'-AGTACT-3'. The cleavage site was determined by comparing the ScaI-cleaved product of a primer-extended M13mp18-SCA DNA, which cont...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 34 2 شماره
صفحات -
تاریخ انتشار 1981